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Genomic malaria surveillance of antenatal care users detects reduced transmission following elimination interventions in Mozambique.

Publicat a: - 2023-11-15 (), DOI: 10.21203/rs.3.rs-3545903/v1

Autors: Mayor A; Brokhattingen N; Matambisso G; da Silva C; Vickers EN; Pujol A; Mbeve H; Cistero P; Maculuve S; Cuna B; Melembe C; Ndimande N; Palmer B; García M; Munguambe H; Lopez JM; Nhamussa L; Simone W; Chidimatembue A; Galatas B; Guinovart C; Rovira-Vallbona E; Saute F; Aide P; Aranda-Díaz A; Greenhouse B; Macete E

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Routine sampling of pregnant women at first antenatal care (ANC) visits could make Plasmodium falciparum genomic surveillance more cost-efficient and convenient in sub-Saharan Africa. We compared the genetic structure of parasite populations sampled from 289 first ANC attendees and 93 children from the community in Mozambique between 2015 and 2019. Samples were amplicon sequenced targeting 165 microhaplotypes and 15 drug resistance genes. Metrics of genetic diversity and relatedness, as well as the prevalence of drug resistance markers, were consistent between the two populations. In an area targeted for elimination, intra-host genetic diversity declined in both populations (p=0.002-0.007), while for the ANC population, population genetic diversity was also lower (p=0.0004), and genetic relatedness between infections were higher (p=0.002) than control areas, indicating a recent reduction in the parasite population size. These results highlight the added value of genomic surveillance at ANC clinics to inform about changes in transmission beyond epidemiological data.

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