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Impact on the Sustainable Development Goals (SDGs)

Analysis of institutional authors

Gabasa, YAuthorCornielle, EAuthorSoto, SmAuthor

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May 8, 2025
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Halogenated 3-Nitro-2H-Chromenes as Potential Agents Against Multidrug-Resistant Bacteria

Publicated to: Antibiotics. 14 (3): 218- - 2025-02-21 14(3), DOI: 10.3390/antibiotics14030218

Authors:

Godinho, PIC; Pérez-Ramos, P; Gabasa, Y; Cornielle, E; Soto, SM; Soengas, RG; Silva, AMS
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Affiliations

Inst Salud Carlos III, CIBER Enfermedades Infecciosas CIBERINFEC - Author
Inst Univ Quim Organometal Enrique Moles, C-Julian Claveria 8 - Author
Univ Aveiro, Dept Chem, LAQV REQUIMTE - Author
Univ Barcelona UB, Fac Med & Ciencies Salut - Author
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Abstract

Introduction/Objectives: Nosocomial infections caused by S. aureus and S. epidermidis resistant strains are an important cause of morbidity and mortality worldwide. Due to the increasing rate of resistance to conventional antibiotics, the discovery of new antibiotic drugs is crucial to keep pace with the evolution of these pathogenic bacterial species. Methods: The 3-nitro-2H-chromene moiety is present in several compounds with potent antibacterial activity; based on these previous studies, we report herein the synthesis of 20 new 2-aryl-3-nitro-2H-chromene derivatives and the evaluation of their antibacterial potential in vitro. Results: Mono-halogenated nitrochromenes showed moderate anti-staphylococcal activity with MIC values of 8-32 mu g/mL, whereas tri-halogenated 3-nitro-2H-chromenes displayed potent anti-staphylococcal activities with MIC values of 1-8 mu g/mL. Notably, 2-(4-bromophenyl)-6-bromo-8-chloro-3-nitro-2H-chromene 5s was the best antibacterial agent in the series against multidrug-resistant strains of S. aureus and S. epidermidis with MIC values of 4 mu g/mL and 1-4 mu g/mL, respectively. Conclusions: nitrochromene 5s shows a good safety profile, so it can be considered as a lead for further development.
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Keywords

A-549 cell lineAcinetobacter baumanniiAntibacterialAntibiotic agentAntibiotic resistanceAntiinfective agentAntimicrobial activityArticleBacterial growthChemical structureChromene derivativeChromenesChromonesCiprofloxacinCytochrome p450 3a4CytotoxicityDerivativesDrug discoveryEscherichia coliGood health and well-beingHalogenated 3 nitro 2h chromeneHalogenated drugHalogenated drugsHospital infectionHumanHuman cellIc50In-vitroInhibitorInhibitory concentrationMass spectrometryMdr bacteriaMedicinal chemistryMinimum inhibitory concentrationMultidrug resistant bacteriumNitro derivativeNitro derivativesProton nuclear magnetic resonancePseudomonas aeruginosaScaffoldStaphylococcus aureusStaphylococcus epidermidisThioredoxin reductaseTobramycinUnclassified drug

Quality index

Bibliometric impact. Analysis of the contribution and dissemination channel

The work has been published in the journal Antibiotics due to its progression and the good impact it has achieved in recent years, according to the agency WoS (JCR), it has become a reference in its field. In the year of publication of the work, 2025, it was in position 17/137, thus managing to position itself as a Q1 (Primer Cuartil), in the category Infectious Diseases.

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Impact and social visibility

From the perspective of influence or social adoption, and based on metrics associated with mentions and interactions provided by agencies specializing in calculating the so-called "Alternative or Social Metrics," we can highlight as of 2026-01-20:

  • The use of this contribution in bookmarks, code forks, additions to favorite lists for recurrent reading, as well as general views, indicates that someone is using the publication as a basis for their current work. This may be a notable indicator of future more formal and academic citations. This claim is supported by the result of the "Capture" indicator, which yields a total of: 5 (PlumX).

With a more dissemination-oriented intent and targeting more general audiences, we can observe other more global scores such as:

    It is essential to present evidence supporting full alignment with institutional principles and guidelines on Open Science and the Conservation and Dissemination of Intellectual Heritage. A clear example of this is:

    • The work has been submitted to a journal whose editorial policy allows open Open Access publication.
    Continuing with the social impact of the work, it is important to emphasize that, due to its content, it can be assigned to the area of interest of ODS 3 - Good Health and Well-Being, with a probability of 85% according to the mBERT algorithm developed by Aurora University.
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    Leadership analysis of institutional authors

    This work has been carried out with international collaboration, specifically with researchers from: Portugal.

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